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KMID : 0043319930160030209
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Archives of Pharmacal Research
1993 Volume.16 No. 3 p.209 ~ p.212
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Anticoagulant Activity of Ilexoside D, a Triterpenoid Saponin from ilex pubescens
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Han Yong-Nam
Song Jae-Ihn
Rhee In-Kyung
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Abstract
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The anti-coagulant activity of ilexoside D isolated from the roots of ilex pubescens Hook. et Am. was investigated in in vivo models of blood coagulation in rats. On oral administration, ilexoside D prolonged the bleeding time and the whole blood recalcified clotting time, but not the plasma recalcified clotting time. In vitor, ilexoside D did not affect the recalciffed clotting times of whole blood, platelet-rich plasma(PRP), and platelet-poor plasma(PPP), while in the presence of tissue factor the compound prologed the reduced proth-rombin times of whole blood, PRP and PPP in the dose-dependent manner. These results indicate that ilexoside D has the anit-tissue factor activity as well as the antithromobotic activity.
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KEYWORD
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Ilexoside D, llex pubescens Hook. et Am., Anti-coagulatn agent, Tissue factor inhibitor
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